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But cytokine production plateaus within 24 to 48 hours, which is why most side effects resolve on their own within that time frame, Desai said.ĬOVID-19 vaccines introduce just enough spike protein to the immune system to trigger a response. These inflammatory chemicals can also cause muscle pain, fatigue, headaches and other symptoms. A higher temperature makes the body less hospitable for the virus, and the rise in temperature stimulates the body to create more immune cells. Cytokines are chemical messengers that help coordinate the immune response and also trigger a fever - which is a common side effect of the COVID-19 vaccines. That’s the balance people have to think about,” he said.All of these immune cells produce inflammatory proteins known as cytokines. “Injection site reactions, some aches and pains, some other potential side effects - versus death. We know the real consequence of not having immunity to COVID, which can lead to somebody’s death,” Javaid told Healthline. “Why are we getting the COVID vaccine to begin with? Because we are in a big pandemic. He noted that it’s important to consider the potential benefits of the vaccine, as well as the potential risks. If you have questions or concerns about the vaccine, Javaid recommends speaking with your healthcare provider. Waleed Javaid, an associate professor of infectious disease at Icahn School of Medicine at Mount Sinai in New York City, he said. So you have more than likely wasted the first dose, if you don’t get the second one in time,” Dr. “Your immunity is incomplete, and it might not be effective.

If you experience mild to moderate side effects after the first dose, that doesn’t mean you should skip the second dose. It’s important to recognize that some side effects from the Pfizer-BioNTech COVID-19 vaccine are common and normal. We need to continue to collect data to make sure it stays that way,” he said. “Of course, we have to continue to monitor going forward. Matthew Heinz, a hospitalist based in Tucson, Arizona, told Healthline. “Based on the large number of folks that have been closely monitored during the study, the patient safety profile is excellent in terms of side effects,” Dr. So far, research has also found that the vaccine has a good safety profile. The available data suggests that after two doses, the vaccine is 95 percent effective at preventing COVID-19. Based on evidence from ongoing clinical trials, the FDA found that the known and potential benefits of the vaccine outweigh the known and potential risks. The FDA issued this authorization after reviewing the available efficacy and safety data on the new vaccine. Under this EUA, Pfizer-BioNTech’s new COVID-19 vaccine can now be distributed in the United States. Visit our coronavirus hub and follow our live updates page for the most recent information on the COVID-19 pandemic.Įarlier this month, the Food and Drug Administration issued its first emergency use authorization (EUA) for a vaccine against COVID-19 in people aged 16 years and older.

Other commonly reported side effects of the Pfizer-BioNTech COVID-19 vaccine include fatigue, headache, and muscle pain.Īll data and statistics are based on publicly available data at the time of publication.

The most commonly reported side effect from the vaccine is injection site reaction.To date, safety data on the vaccine has been collected from 37,586 participants enrolled in an ongoing phase 3 clinical trial.Share on Pinterest Healthcare workers across the nation are getting the COVID-19 vaccine.